Here is the standardised PICO analysis for the fourth uploaded article:


Full Title

Effectiveness of advance care planning programmes in improving end-of-life outcomes for individuals with dementia and their caregivers in nursing homes: protocol for a systematic review and meta-analysis

Authors: Yu-Tai Lo, Yi-Jhen Chen, Jheng-Yan Wu, Chih-Cheng Lai

JournalBMJ Open, 2024; 14:e088646

DOI10.1136/bmjopen-2024-088646

Type of Study

Protocol for a systematic review and meta-analysis


PICO Summary

Population (P)

  • Individuals with dementia residing in nursing homes, and their caregivers
  • Includes adults aged 65+ with advanced cognitive decline, likely nearing end of life
  • Reflects global populations, but special attention to studies in the US, UK, and Europe
  • Also includes family caregivers as secondary population

Intervention (I)

  • Advance Care Planning (ACP) programmes
    • May include:
      • Structured EoL conversations
      • Documentation of advance directives
      • Family-inclusive decision-making
      • Multicomponent ACP interventions (education, discussion, and documentation)

Comparison (C)

  • Usual care (no formal ACP programme)
  • May include informal or inconsistent EoL care planning

Outcomes (O)

Person-centred outcomes:

  1. Quality of life (patient-focused)
  2. Caregiver satisfaction

Process outcomes:

3. Advance directives completion rate (proportion with documented EoL preferences)

4. Uptake of ACP discussion (frequency of ACP conversations)

Health system outcome:

5. Comfort in the last week of life

  • Captures alignment of care with patient wishes and symptom management 

Findings Summary (Protocol Stage)

  • No results yet: this is a protocol, not a completed review
  • Will include RCTs and observational studies
  • Designed using PRISMA-P, Cochrane methods, and GRADE certainty framework
  • Aims to synthesise evidence across multiple EoL domains (clinical, emotional, communicative)
  • Seeks to inform best practice guidelines and future ACP implementation strategies in long-term care settings

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